antibacterial effects of rue (ruta graveolens) extract against pathogenic bacteria (lactococcus garvieae & aeromonas hydrophila)

rue, ruta graveolens, is a medicinal plant in traditional medicine that has several therapeutic properties such as anti-carcinogenic agent, antioxidant, anti-inflammatory, antimicrobial, hypotensive, and spasmolytic. this study was carried out to evaluate the antibacterial effects of the etanolic extract of rue against piscine pathogenic bacteria viz. lactococcus garvieae and aeromonas hydrophila isolated in iranian trout farms in compare with common antibiotics (erythromycin, tetracycline, sulfamethoxazole and enrofloxacin), using disc diffusion and serial macro dilution methods. the minimal inhibitory concentrations (mic) and the minimum bactericidal concentration (mbc) of extract were also determined. the results showed that the etanolic extract of r. graveolens has no inhibitory effect on growth of both gram positive and negative evaluated bacteria which may be related to resistant character of the bacteria, extraction method and/or absence of a particular chemical compound in the extracts of the plant.